Read this from Wikipedia:
Grapefruit and grapefruit juice have been found to interact with numerous drugs (at least 85 by the latest count), in many cases resulting in adverse effects.[1] Organic compounds, which are furanocoumarin derivatives, interfere with the hepatic and intestinalenzyme cytochrome P450 isoform CYP3A4 and are believed to be primarily responsible for the effects of grapefruit on the enzyme. Bioactive compounds in grapefruit juice may also interfere with P-glycoprotein and organic anion transporting polypeptides (OATPs), either increasing or decreasing the bioavailability of a number of drugs.Pomelo (the Asian fruit which was crossed with an orange to produce grapefruit) also contains high amounts of furanocoumarin derivatives. Some grapefruit-pomelo hybrids have practically no furanocoumarincontent, and one is a commercially viable seedless type.[2]
Grapefruit essential oil DOES contain furanocoumarins, so if your doctor or nurse practitioner tells you not to use it then you'd better listen... Lime and Bergamot also contain furanocoumarins.
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